Subchronic exposure to a glyphosate-based herbicide causes dysplasia in the digestive tract of Wistar rats

Glyphosate-based herbicides (GBH) are the most widely used herbicide for treatment of crops in world. The digestive tract is one first systems exposed to pesticides, and damage this system can affect general health individuals. aim study was evaluate effects subchronic inhalation oral exposure GBH on rats. Six groups Wistar rats (male female) were nebulization with three concentrations [3.71 × 10−3 grams active ingredient per hectare (g.a.i./ha), 6.19 g.a.i./ha 9.28 g.a.i./ha] administered orally or by 75 days. Bone marrow cells, smears tongue fragments tongue, oesophagus, stomach intestine collected histopathological analysis. Congestion, inflammation, an increase number mast cells nucleoli-organizing regions detected GBH. Females had a higher than males. Animals showed dysplasia oesophagus small large regardless sex. Gastric changes not observed. increased micronucleus formation. Our data indicate that causes allergies dysplastic lesions has genotoxic potential.